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Malarone 250/100 12 Tablets/Pack


Malarone 250/100 12 Tablets/Pack

Malarone 250mg Atovaquone 100mg Proguanil


Product Name
Malarone 250/100 12 Tablets/Pack
Active Ingredient
Atovaquone and Proguanil
Manufacturer
GlaxoSmithKline
Product Type
Anti-malarial (schizonticide)
Product expiry date we are currently shipping
Mar 2018
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Malarone 250/100 Atovaquone/Proguanil 12 Tablets
$9.10 per Tablet
| $109.25 
Malarone 250/100 Atovaquone/Proguanil 24 Tablets
$8.39 per Tablet
| $201.25 
Malarone 250/100 Atovaquone/Proguanil 36 Tablets
$7.67 per Tablet
| $276.00 
Malarone tablets 250/100contain a combination of two anti-malarial drugs, atovaquone and proguanil, that are used in the treatment and prevention of malaria, an infectious disease caused by the parasite Plasmodium falciparum and transmitted by the mosquito.

Malarone general information

What is Malarone used for?

Malarone tablets 250/100 are use treat malaria, an infection caused by the protozoan (single cell) parasitic organism Plasmodium falciparum the most common and most dangerous species of Plasmodium. The parasite is carried by mosquitoes and is transmitted by a bite from an infected female mosquito when the first stage of the life cycle called the sporozoite is injected into the blood, while the mosquito is feeding. It then migrates to the liver, where it differentiates, grows and multiplies. The next stage of the plasmodium life cycle called merozoite is released into the blood, infects red blood cells and transforms into the trophozoite that causes destruction of red blood cells. Some merozoites transform into gametocytes and are taken up by a mosquito when feeding on blood to begin a new cycle. Symptoms of malaria, including fever, shivering, headache, vomiting, muscle pain, and joint pain, usually appear 10 to 15 days after the mosquito bite. However, if left untreated, malaria can quickly become life-threatening, causing anaemia and brain damage and disrupting the blood supply to vital organs. Malarone tablets 250/100 disrupt the life cycle of the plasmodium and prevent further destruction of red blood cells; and they are particularly useful in areas where Plasmodium is resistant to other quinoline anti-malarial drugs like chloroquine and quinine.

How does Malarone work?

Malarone tablets 250/100 contain a combination of two anti-malarial drugs that are used to treat malaria by acting as a combination schizontocide to kill the schizont infective stage of the immature plasmodium parasite; also the stage of the plasmodium parasite that causes destruction of red blood cells resulting in the symptoms of malaria. During the destruction of red blood cells, the plasmodium parasite digests the oxygen carrying protein haemoglobin forming the toxic compound haem which is converted to the insoluble crystalline form haemozoin that is not toxic to plasmodium. Malarone tablets 250/100 work by disrupting parasitic nucleic acid synthesis and this prevents the parasite from being able to replicate and thereby prevents the spread of the infection and transmission of malaria. Atovaquone and proguanil hydrochloride in Malarone tablets both block the biosynthesis of pyrimidines, which are the nucleoside bases that make up the structure of DNA and RNA and are important in the replication of nucleic acids. Atovaquone in Malarone tablets acts as a selective inhibitor of mitochondrial electron transport in the plasmodium parasite cell. Proguanil hydrochloride in Malarone tablets is metabolised into cycloguanil and this metabolite inhibits the enzyme dihydrofolate reductase, which is involved in deoxythymidylate synthesis, an important step in the synthesis of nucleic acid. Proguanil also has a synergistic effect on the action of Atovaquone, such that the combination of the two drugs is more effective than either drug alone.

What does Malarone contain?

Malarone tablets contain the active ingredients Atovaquone (250mg) and proguanil hydrochloride (100mg) both anti-malarial drugs used for treatment and prevention of infection with Plasmodium falciparum that causes malaria. They also contain poloxamer 188, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, povidone K30, sodium starch glycollate, magnesium stearate, hypromellose, titanium dioxide, iron oxide red E172, macrogol 400, macrogol 8000.

Treating malaria with Malarone

Malarone tablets 250/100 contain two anti-malarial drugs atovaquone and proguanil hydrochloride that are used in combination for the treatment and prevention of malaria, an infectious disease caused by the protozoan (single cell) parasitic organism Plasmodium falciparum and carried by the mosquito. The infective stage of the immature plasmodium parasite, the sporozoite, is transmitted by a mosquito bite into the blood when the mosquito is feeding. It migrates to the liver where it differentiates, grows and multiplies. The next stage of the plasmodium life cycle called merozoite is released into the blood, infects red blood cells and transforms into the trophozoite that causes destruction of red blood cells. Some merozoites transform into gametocytes and are taken up by a mosquito when feeding on blood to begin a new cycle. Symptoms of malaria, including fever, shivering, headache, vomiting, muscle pain, and joint pain, usually appear 10 to 15 days after the mosquito bite. However, if left untreated, malaria can quickly become life-threatening, causing anaemia and brain damage and disrupting the blood supply to vital organs. Atovaquone and proguanil hydrochloride in Malarone tablets both work by blocking nucleic acid synthesis by the Plasmodium parasite, each by a different mechanism of action. This disrupts the life cycle of the plasmodium as well as preventing further destruction of red blood cells and is particularly useful in areas where Plasmodium is resistant to other quinoline anti-malarial drugs like chloroquine and quinine.

What are the side effects of Malarone?

The most commonly reported side effects when taking Malarone tablets 250/100 include: gastrointestinal upset (nausea, vomiting, diarrhoea and abdominal pain), headache, insomnia dizziness, skin rash and cough.

When should Malarone not be used?

You should not use Malarone tablets 250/100 if you:
  • are allergic to atovaquone and proguanil or any ingredients in Malarone tablets
  • are pregnant or are breastfeeding
  • have severe kidney disease
  • have severe malaria, including cerebral malaria or pulmonary oedema or a relapse of malaria
  • have vomiting or diarrhoea
  • are taking medicines that interact with Malarone, including, antibiotics like rifampicin, rifabutin and tetracycline, anticoagulants like warfarin, metoclopramide for nausea, indinavir for HIV infection

What medications interact with Malarone?

Several medications interact with Malarone tablets 250/100 and should either not be taken while you are taking Malarone or only after discussion and instruction from your doctor:
  • Drugs that affect Malarone: rifampicin, rifabutin and tetracycline, metoclopramide for nausea
  • Drugs that are affected by Malarone: anticoagulants like warfarin, indinavir for HIV infection

How should Malarone be taken?

You should take your Malarone tablets 250/100 swallowed whole, once daily at the same time each day, with a glass of water and food or with a milky drink. The dose you take depends on your body weight and should be as recommended by your doctor. If you vomit within an hour of taking a Malarone tablet you should repeat the dose. For prophylaxis (prevention) of malaria you should take your Malarone tablets 1 to 2 days before entering a malaria-endemic area, continue daily until 7 days after leaving the area. For treatment of malaria you should take your Malarone tablets once daily as a single dose for three consecutive days.

How long should you take Malarone?

For prophylaxis of malaria you should take your Malarone tablets 250/100 1 to 2 days before entering a malaria-endemic area, continue daily until 7 days after leaving the area. For treatment of malaria you should take your Malarone tablets once daily as a single dose for three consecutive days.

Missed dose of Malarone

If you miss a dose of Malarone tablets 250/100 take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Malarone be stored?

You should store your Malarone tablets 250/100 below 30°C in a cool dry place.

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